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Nanoparticles for Cancer Therapy: Current Progress and Challenges

Nanoscale research letters, 2021-12, Vol.16 (1), p.173-21, Article 173 [Peer Reviewed Journal]

The Author(s) 2021 ;2021. The Author(s). ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1931-7573 ;ISSN: 1556-276X ;EISSN: 1556-276X ;DOI: 10.1186/s11671-021-03628-6 ;PMID: 34866166

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Title:
Nanoparticles for Cancer Therapy: Current Progress and Challenges
Author: Gavas, Shreelaxmi ; Quazi, Sameer ; Karpiński, Tomasz M.
Subjects: Biocompatibility ; Cancer ; Cancer therapies ; Cellular targeting ; Chemistry and Materials Science ; Chemotherapy ; Cryosurgery ; Cytotoxicity ; Drug delivery ; Drug delivery systems ; Drug resistance ; Immunotherapy ; In vivo methods and tests ; Materials Science ; Molecular Medicine ; Morbidity ; Multidrug resistance ; Nano Review ; Nanochemistry ; Nanoparticles ; Nanoscale Science and Technology ; Nanotechnology ; Nanotechnology and Microengineering ; Permeability ; Radiation ; Radiation therapy ; Toxicity ; Tumors
Is Part Of: Nanoscale research letters, 2021-12, Vol.16 (1), p.173-21, Article 173
Description: Cancer is one of the leading causes of death and morbidity with a complex pathophysiology. Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and immunotherapy. However, limitations such as lack of specificity, cytotoxicity, and multi-drug resistance pose a substantial challenge for favorable cancer treatment. The advent of nanotechnology has revolutionized the arena of cancer diagnosis and treatment. Nanoparticles (1–100 nm) can be used to treat cancer due to their specific advantages such as biocompatibility, reduced toxicity, more excellent stability, enhanced permeability and retention effect, and precise targeting. Nanoparticles are classified into several main categories. The nanoparticle drug delivery system is particular and utilizes tumor and tumor environment characteristics. Nanoparticles not only solve the limitations of conventional cancer treatment but also overcome multidrug resistance. Additionally, as new multidrug resistance mechanisms are unraveled and studied, nanoparticles are being investigated more vigorously. Various therapeutic implications of nanoformulations have created brand new perspectives for cancer treatment. However, most of the research is limited to in vivo and in vitro studies, and the number of approved nanodrugs has not much amplified over the years. This review discusses numerous types of nanoparticles, targeting mechanisms, and approved nanotherapeutics for oncological implications in cancer treatment. Further, we also summarize the current perspective, advantages, and challenges in clinical translation.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 1931-7573
ISSN: 1556-276X
EISSN: 1556-276X
DOI: 10.1186/s11671-021-03628-6
PMID: 34866166
Source: GFMER Free Medical Journals
PubMed Central
Alma/SFX Local Collection
ProQuest Central
DOAJ Directory of Open Access Journals
Springer Nature OA Free Journals

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Nanoparticles for Cancer Therapy: Current Progress and Challenges

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