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Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Nature genetics, 2012-06, Vol.44 (6), p.670-675 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2012 ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2261 ;PMID: 22544366 ;CODEN: NGENEC

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Title:
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Author: ELLINOR, Patrick T ; LUNETTA, Kathryn L ; BIS, Joshua C ; CHUNG, Mina K ; DÖRR, Marcus ; OZAKI, Kouichi ; ROBERTS, Jason D ; GUSTAV SMITH, J ; PFEUFER, Arne ; SINNER, Moritz F ; LOHMAN, Kurt ; JINGZHONG DING ; ALBERT, Christine M ; SMITH, Nicholas L ; SMITH, Jonathan D ; RIENSTRA, Michiel ; RICE, Kenneth M ; VAN WAGONER, David R ; MAGNANI, Jared W ; WAKILI, Reza ; CLAUSS, Sebastian ; ROTTER, Jerome I ; STEINBECK, Gerhard ; GLAZER, Nicole L ; LAUNER, Lenore J ; DAVIES, Robert W ; BORKOVICH, Matthew ; HARRIS, Tamara B ; HONGHUANG LIN ; VÖLKER, Uwe ; VÖLZKE, Henry ; MILAN, David J ; HOFMAN, Albert ; BOERWINKLE, Eric ; RITCHIE, Marylyn D ; CHEN, Lin Y ; SOLIMAN, Elsayed Z ; VOIGHT, Benjamin F ; GUO LI ; CHAKRAVARTI, Aravinda ; KUBO, Michiaki ; TEDROW, Ushab ; ROSE, Lyndam ; MRIDKER, Paul ; CONEN, David ; SMITH, Albert V ; TSUNODA, Tatsuhiko ; FURUKAWA, Tetsushi ; SOTOODEHNIA, Nona ; ARKING, Dan E ; MÜLLER-NURASYID, Martina ; KRIJTHE, Bouwe P ; LUBITZ, Steven A
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - genetics ; Atrial fibrillation ; Atrial Fibrillation - genetics ; Biological and medical sciences ; Cardiac and Cardiovascular Systems ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Child ; Child, Preschool ; Chromosomes ; Clinical Medicine ; Disease susceptibility ; European Continental Ancestry Group - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gene loci ; Gene mutations ; Genealogy ; Genetic aspects ; Genetic Loci ; Genetic Predisposition to Disease - genetics ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Genomes ; Health aspects ; Heart ; Humans ; Infant ; Infant, Newborn ; Kardiologi ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Meta-analysis ; Methods ; Middle Aged ; Musculoskeletal system ; Mutation ; Polymorphism, Single Nucleotide ; Risk Factors ; Signal transduction ; Young Adult
Is Part Of: Nature genetics, 2012-06, Vol.44 (6), p.670-675
Description: Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
Publisher: New York, NY: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
ISSN: 1546-1718
EISSN: 1546-1718
DOI: 10.1038/ng.2261
PMID: 22544366
CODEN: NGENEC
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

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Meta-analysis identifies six new susceptibility loci for atrial fibrillation

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2012 ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2261 ;PMID: 22544366 ;CODEN: NGENEC

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