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Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation

Revista de la Facultad de Medicina Humana, 2020-01, Vol.20 (1), p.94-98 [Peer Reviewed Journal]

ISSN: 1814-5469 ;EISSN: 2308-0531 ;DOI: 10.25176/RFMH.v20i1.2552

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  • Title:
    Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation
  • Author: Nathalie D. Amado-Cornejo ; Geraldine Atusparia-Flores ; Maricielo V. Huamán-Cabrera ; Ángela Méndez-Pajares ; Etty Prado-Asencios ; Hilda Jurupe-Chico ; Vilma Herencia-Reyes
  • Subjects: edema ; inflammation ; manihot esculenta crantz
  • Is Part Of: Revista de la Facultad de Medicina Humana, 2020-01, Vol.20 (1), p.94-98
  • Description: Introduction: Manihot esculenta Crantz (yucca) leaves have been used around the world and over time in order to decrease the anti-inflammatory response. Objective: To evaluate the anti-inflammatory activity of the ethanolic extract of the Manihot esculenta Crantz leaf in rats. Methods: An experimental study was conducted. The study population included 60 albino rats sp. Rattus novergicus, distributed in 4 groups of 15 rats each. A homogeneous solution of ethanolic extract of Manihot esculenta Crantz leaves was used for intraperitoneal administration. Carrageenan was used as an inflammatory inducer that was administered intradermally; for the measurement of plantar edema, the Digital Water Plethysmometer (LE7500) was used. Tween 80 / water solution (1:10) was administered to the negative control group at a dose of 1mL./100g., To the betamethasone positive control group 4mg / Kg and to treatment groups 1 and 2 Manihot esculenta Crantz, 2 mg / kg and 4 mg / kg, respectively. The 1-tail ANOVA test and the Tukey post hoc test were used for comparisons between the groups. Results: In 37.67% of treatment group 2 a reduction in edema was observed 3 hours after administering Manihot esculenta Crantz (p <0.05). In both administration groups of Manihot esculenta Crantz there was a nonsignificant trend to reduce plantar edema with values close to significance. Conclusion: The Manihot esculenta Crantz ethanolic extract at a 4 mg / kg dose probably have anti-inflammatory activity in this animal model of acute inflamation.
  • Publisher: Universidad Ricardo Palma
  • Language: Spanish
  • Identifier: ISSN: 1814-5469
    EISSN: 2308-0531
    DOI: 10.25176/RFMH.v20i1.2552
  • Source: DOAJ Directory of Open Access Journals
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