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All-optical observation on activity-dependent nanoscale dynamics of myelinated axons

Neurophotonics (Print), 2023-01, Vol.10 (1), p.015003-015003 [Peer Reviewed Journal]

The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. ;2023 The Authors. ;2023. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2023 The Authors 2023 The Authors ;ISSN: 2329-423X ;EISSN: 2329-4248 ;DOI: 10.1117/1.NPh.10.1.015003 ;PMID: 36699624

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  • Title:
    All-optical observation on activity-dependent nanoscale dynamics of myelinated axons
  • Author: Kwon, Junhwan ; Lee, Sungho ; Jo, Yongjae ; Choi, Myunghwan
  • Subjects: Axons ; Brain ; Brain architecture ; Brain slice preparation ; Cerebrospinal fluid ; Lasers ; Microscopy ; Morphology ; Myelin ; Optics ; Research Papers ; Spectrum analysis
  • Is Part Of: Neurophotonics (Print), 2023-01, Vol.10 (1), p.015003-015003
  • Description: In the mammalian brain, rapid conduction of neural information is supported by the myelin, the functional efficacy of which shows steep dependence on its nanoscale cytoarchitecture. Although previous studies have suggested that neural activity accompanies nanometer-scale cellular deformations, whether neural activity can dynamically remodel the myelinated axon has remained unexplored due to the technical challenge in observing its nanostructural dynamics in living tissues. We aim to observe activity-dependent nanostructural dynamics of myelinated axons in a living brain tissue. We introduced a novel all-optical approach combining a nanoscale dynamic readout based on spectral interferometry and optogenetic control of neural excitation in an acute brain slice preparation. In response to optogenetically evoked neuronal burst firing, the myelinated axons exhibited progressive and reversible spectral redshifts, corresponding to the transient swelling at a subnanometer scale. We further revealed that the activity-dependent nanostructural dynamics was localized to the paranode. Our all-optical studies substantiate that myelinated axon exhibits activity-dependent nanoscale swelling, which potentially serves to dynamically tune the transmission speed of neural information.
  • Publisher: United States: Society of Photo-Optical Instrumentation Engineers
  • Language: English
  • Identifier: ISSN: 2329-423X
    EISSN: 2329-4248
    DOI: 10.1117/1.NPh.10.1.015003
    PMID: 36699624
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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