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Brief Report: Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Persons With HIV

Journal of acquired immune deficiency syndromes (1999), 2020-08, Vol.84 (4), p.400-404 [Peer Reviewed Journal]

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Aug 1, 2020 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/QAI.0000000000002359 ;PMID: 32235172

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Title:
Brief Report: Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Persons With HIV
Author: Kaplan, Alyson ; Simon, Tracey G ; Henson, Jacqueline B ; Wang, Thomas ; Zheng, Hui ; Osganian, Stephanie A ; Rosenblatt, Russell ; Lake, Jordan ; Corey, Kathleen E
Subjects: Adult ; Apnea ; Body mass ; Body Mass Index ; Body size ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; CD4 antigen ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes - cytology ; Cell culture ; Cerebral infarction ; Confidence intervals ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Cross-Sectional Studies ; Diabetes mellitus ; Dyslipidemia ; Fatty liver ; Female ; Heart diseases ; HIV ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Hypertension ; Identification methods ; Ischemia ; Liver ; Liver diseases ; Lymphocytes T ; Male ; Middle Aged ; Myocardial infarction ; Non-alcoholic Fatty Liver Disease - epidemiology ; Risk analysis ; Risk Factors ; Risk management ; Sleep ; Sleep disorders ; Statistical analysis ; Transient ischemic attack ; Vascular diseases
Is Part Of: Journal of acquired immune deficiency syndromes (1999), 2020-08, Vol.84 (4), p.400-404
Description: BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) and HIV are independently associated with cardiovascular disease (CVD). However, the factors associated with NAFLD in persons living with HIV (PWH) and whether CVD is more frequent in PWH with NAFLD are currently unknown. METHODS:From the Partners HealthCare Research Patient Data Registry, we identified PWH with and without NAFLD between 2010 and 2017. NAFLD was defined using validated histological or radiographic criteria. CVD was defined by an ICD-9 diagnosis of coronary artery disease, myocardial infarction, coronary revascularization, peripheral vascular disease, heart failure, transient ischemic attack, or stroke and was confirmed by clinician review. Multivariable logistic regression was performed to examine the relationship between NAFLD and CVD. RESULTS:Compared with PWH without NAFLD (n = 135), PWH with NAFLD (n = 97) had higher body mass index and more frequently had hypertension, obstructive sleep apnea, diabetes mellitus, dyslipidemia, coronary artery disease, and CVD (P < 0.01 for all). PWH with NAFLD were also more likely to have CD4 T-cell counts (CD4) <200 cells/mm. In multivariable models, the presence of NAFLD was significantly associated with CVD (adjusted odds ratio 3.08, 95% confidence interval1.37 to 6.94) and CD4 <200 cells/mm (adjusted odds ratio 4.49, 95% confidence interval1.74 to 11.55). CONCLUSION:In PWH, CVD was independently associated with prevalent NAFLD after controlling for traditional CVD risk factors. NAFLD was also associated with CD4 <200 cells/mm, suggesting that immune dysfunction may be related to NAFLD. Both CVD and low CD4 count as risk factors for NAFLD require prospective evaluation.
Language: English
Identifier: ISSN: 1525-4135
EISSN: 1944-7884
DOI: 10.1097/QAI.0000000000002359
PMID: 32235172
Source: MEDLINE
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Brief Report: Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Persons With HIV

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Aug 1, 2020 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/QAI.0000000000002359 ;PMID: 32235172

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